Sodium Acetate → Bicyclo[3.2.1]octan-8-ol, 1,5-dimethyl-, 8-acetate

HRID 1732861ノート

反応式

HRID 1732861 の反応式
[CH3:1][C:2]12[CH:9](Br)[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2.[C:12]([O-:15])(=[O:14])[CH3:13].[Na+]>C(O)(=O)C.[Cu]Cl>[CH3:1][C:2]12[CH:9]([O:15][C:12](=[O:14])[CH3:13])[C:6]([CH3:11])([CH2:7][CH2:8]1)[CH2:5][CH2:4][CH2:3]2

参加物

5

反応物 2

HCID 517045Sodium AcetateHCID 5323829HCID 5323829、化合物

生成物 1

HCID 173489Bicyclo[3.2.1]octan-8-ol, 1,5-dimethyl-, 8-acetate

試薬・触媒・溶媒 2

HCID 62652Cuprous chloride触媒HCID 176Acetic Acid溶媒

実験手順

5 g of 1,5-dimethyl-8-bromobicyclo[3,2,1]octane was boiled under reflux for 18 hours in acetic acid in the presence of sodium acetate and copper(I) chloride. The reaction mixture was cooled and filtered, diluted with water and extracted with pentane. The pentane solution was washed with water and an aqueous sodium bicarbonate solution, dired, evaporated and fractionally distilled. 1,5-dimethyl-8-acetoxy-bicyclo[3,2,1]octane was obtained in good yield. 1,5-dimethyl-8-acetoxybicyclo[3,2,1]octane was also obtained in a similar manner starting from the 8-iodo compound described in Example 3.

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. additiondiluted with water
  4. extractionextracted with pentane
  5. washThe pentane solution was washed with water
  6. customevaporated
  7. distillationfractionally distilled

出典と根拠

ORDレコード
ord-0eceffbef72246bdb33234096b68b253
出典データセット
uspto-grants-1980_12
特許番号
US04239707

反応ノート

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