L-Lysine → Lysine 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetate

HRID 1732890

反応式

HRID 1732890 の反応式
[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([C:14]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[O:15])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7].[NH2:21][C@H:22]([C:28]([OH:30])=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][NH2:27]>C(O)C.O>[Cl:1][C:2]1[C:12]([Cl:13])=[C:11]([C:14]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[O:15])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7].[NH2:21][C@H:22]([C:28]([OH:30])=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][NH2:27]

参加物

5

反応物 2

HCID 5962L-LysineHCID 38409Tienilic Acid

生成物 1

HCID 70595659Lysine 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetate

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

33.1 g 2,3-dichloro-4-(2-thienylcarbonyl)-phenoxyacetic acid and 150 ml ethanol were added at about 40° C. to a solution of 14.6 g of L (-)-lysine in 200 ml anhydrous ethanol. Using the method of Example 1, there was precipitated a salt with melting point 226° C. Again the infra-red spectrum showed than addition salt was formed. A solution of 2.5 g product salt in 100 ml water had a pH of 6.2.

後処理

  1. customwas precipitated a salt with melting point 226° C
  2. additionAgain the infra-red spectrum showed than addition salt
  3. customwas formed

出典と根拠

ORDレコード
ord-72dc52542eec4efa8a9568dd0698a6ad
出典データセット
uspto-grants-1980_12
特許番号
US04239771

関連ノート

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