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p-Toluenesulfonic acid monohydrate → 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 反応物 | 2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate | HCID 86097516 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile | HCID 51041427 | — |
反応手順
2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737166B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-c5a4eb7304a7465ea090a9d1fd91deef |
| 出典メモ | uspto-grants-2010_06 |