p-Toluenesulfonic acid monohydrate → 6-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile

HRID 17329

反応式

HRID 17329 の反応式
[C:1]([O:4][C:5]1[C:10]([F:11])=[C:9]([Br:12])[C:8]([CH3:13])=[C:7]([C:14]#[N:15])[C:6]=1[NH2:16])(=O)[CH3:2].O.[C:18]1(C)C=CC(S(O)(=O)=O)=C[CH:19]=1>C1(C)C=CC=CC=1>[Br:12][C:9]1[C:10]([F:11])=[C:5]2[O:4][C:1]([CH:2]3[CH2:19][CH2:18]3)=[N:16][C:6]2=[C:7]([C:14]#[N:15])[C:8]=1[CH3:13]

参加物

4

反応物 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 860975162-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate

生成物 1

HCID 510414276-Bromo-2-cyclopropyl-7-fluoro-5-methylbenzoxazole-4-carbonitrile

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.

後処理

  1. temperatureunder reflux for 19 hours

出典と根拠

ORDレコード
ord-c5a4eb7304a7465ea090a9d1fd91deef
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

関連ノート

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