Hydrochloric Acid → 1-(4-Hydroxy-3-thienyl)ethanone

HRID 1732933ノート

反応式

HRID 1732933 の反応式
[OH:1][CH:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH2:3]1.S(Cl)(Cl)(=O)=O.Cl>C(Cl)Cl>[OH:1][C:2]1[C:6]([C:7](=[O:9])[CH3:8])=[CH:5][S:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 24648Sulfuryl chlorideHCID 20300157HCID 20300157、化合物

生成物 1

HCID 217161-(4-Hydroxy-3-thienyl)ethanone収率 77%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2.88 Parts of 3-hydroxy-4-acetyldihydrothiophene are introduced into 20 parts by volume of dried methylene chloride; a solution of 1.7 parts by volume of sulfuryl chloride in 20 parts by volume of dried methylene chloride is added in the course of 10 minutes at 0° C. During the reaction, nitrogen is passed in, in order to expel the hydrochloric acid formed. After 30 minutes, the reaction mixture is worked up. The end product is isolated from the reaction mixture by the method described in Example 1c. 2.22 parts (77% of theory) of 3-hydroxy-4-acetylthiophene of melting point 44°-47° C. are obtained.

後処理

  1. customDuring the reaction, nitrogen
  2. customformed
  3. customThe end product is isolated from the reaction mixture by the method

出典と根拠

ORDレコード
ord-36eaf097a39d4d3783eee7580f8473d7
出典データセット
uspto-grants-1980_12
特許番号
US04239897

反応ノート

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