Bromine → HCID 20303432、化合物

HRID 1732996ノート

反応式

HRID 1732996 の反応式
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:7]=2)[CH:5]=[CH:4][CH:3]=[N:2]1.[Br:16]Br>C(Cl)(Cl)(Cl)Cl>[Br:16][C:4]1[CH:3]=[N:2][N:1]([C:6]2[CH:7]=[CH:8][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][CH:11]=2)[CH:5]=1

参加物

4

反応物 2

HCID 24408BromineHCID 12094244[4-(1H-Pyrazol-1-yl)phenyl]acetic acid

生成物 1

HCID 20303432HCID 20303432、化合物収率 98%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒2 回

実験手順

20.2 g (100 mmoles) of 4-(pyrazol-1-yl)phenylacetic acid are dissolved in 400 ml of carbon tetrachloride. 16 g of bromine (200 mmoles) in 400 ml of carbon tetrachloride are added dropwise, with ice cooling, to the resulting solution. After subsequent stirring for half an hour at room temperature, washing with sodium dithionite solution is effected; this is followed by drying with sodium sulfate and, finally, by evaporation to dryness to obtain 27.5 g (98% of theory) of 4-(4-bromo-pyrazol-1-yl)phenylacetic acid, m.p. 187° C. (from acetonitrile).

後処理

  1. washwashing with sodium dithionite solution
  2. dry with materialby drying with sodium sulfate
  3. customfinally, by evaporation to dryness

出典と根拠

ORDレコード
ord-26a8ee40f231404b9ea6c16fc754a339
出典データセット
uspto-grants-1980_12
特許番号
US04239901

反応ノート

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