Ethanol → 2-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]([CH3:18])[C:15]([OH:17])=[O:16])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[C:11]([Cl:13])[CH:10]=[N:9]1.S(=O)(=O)(O)O.[CH2:24](O)[CH3:25]>>[CH2:24]([O:16][C:15](=[O:17])[CH:14]([C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH:12]=[C:11]([Cl:13])[CH:10]=[N:9]2)=[C:2]([Cl:1])[CH:3]=1)[CH3:18])[CH3:25]

参加物

反応物 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 203034102-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid

生成物 1

HCID 539945502-[3-Chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester収率 83%

実験手順

14.25 g (50 mmoles) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid, 150 ml of ethanol and 7 g of concentrated sulfuric acid are heated to the boil for 10 hours. Concentration is effected, followed by pouring onto ice water, extracting with diethyl ether, washing of the organic solution with sodium hydrogen carbonate solution, drying the organic solution and distilling it to obtain 12.4 g (83% of theory) of 2-[3-chloro-4-(4-chloropyrazol-1-yl)phenyl]propionic acid ethyl ester (b.p. 134° C./3·10-2 mm Hg).