Hydrochloric Acid → 2-Benzoylamino-3-cyano-4-tert.-butyl-thiophene

HRID 1733140ノート

反応式

HRID 1733140 の反応式
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[S:12][CH:13]=[C:14]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:15]=1[C:16]#[N:17].Cl>C1(C)C=CC=CC=1>[C:1]([NH:10][C:11]1[S:12][CH:13]=[C:14]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:15]=1[C:16]#[N:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 5968662-Amino-4-(1,1-dimethylethyl)-3-thiophenecarbonitrile

生成物 1

HCID 203003552-Benzoylamino-3-cyano-4-tert.-butyl-thiophene収率 81.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

After adding 29.4 g (0.21 mole) of benzoyl chloride, a mixture of 36 g (0.2 mole) of 2-amino-3-cyano-4-tert.-butyl-thiophene and 200 ml of toluene was boiled until the evolution of hydrogen chloride had ended (4 hours). Thereafter, the reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator. The residue was recrystallized from methanol. 46.4 g of 2-benzoylamino-3-cyano-4-tert.-butyl-thiophene of melting point 130° C. were obtained in this manner.

後処理

  1. custom(4 hours)
  2. filtrationThereafter, the reaction mixture was filtered
  3. concentrationthe filtrate was concentrated on a rotary evaporator
  4. customThe residue was recrystallized from methanol

出典と根拠

ORDレコード
ord-a346e0b9e8444844804981ccc737072b
出典データセット
uspto-grants-1980_12
特許番号
US04240820

反応ノート

読み込み中…