Acetyl chloride → HCID 20300372、化合物

HRID 1733145ノート

反応式

HRID 1733145 の反応式
C(N(CC)CC)C.[NH2:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15].[C:21](Cl)(=[O:23])[CH3:22]>C1(C)C=CC=CC=1>[C:21]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:13]=1[C:14]([NH2:16])=[O:15])(=[O:23])[CH3:22]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 16793423HCID 16793423、化合物

生成物 1

HCID 20300372HCID 20300372、化合物収率 80.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

21.2 g (0.21 mole) of triethylamine were first added to a suspension of 39.6 g (0.2 mole) of 2-amino-3-aminocarbonyl-4-tert.-butyl-thiophene in 300 ml of toluene, and 16.5 g (0.21 mole) of acetyl chloride were then added dropwise. After the exothermic reaction had ended, the mixture was worked up by filtering off the solid product and washing it with water. 38.6 g of 2-acetylamino-3-aminocarbonyl-4-tert.-butyl-thiophene of melting point 251° C. were obtained in this manner.

後処理

  1. additionwere then added dropwise
  2. customAfter the exothermic reaction
  3. filtrationby filtering off the solid product
  4. washwashing it with water

出典と根拠

ORDレコード
ord-5f46feac3e124eb28d3a233b453c7af9
出典データセット
uspto-grants-1980_12
特許番号
US04240820

反応ノート

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