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Hydrochloric Acid → 2-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 2-Amino-4,5-dimethyl-3-furancarbonitrile | HCID 290220 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide | HCID 16227354 | 122.3% |
反応手順
20.4 g (0.1 mole) of 2-amino-3-cyano-4,5-dimethylfurane and 17.5 g (0.155 mole) of chloroacetyl chloride were boiled in 200 ml of toluene until the evolution of hydrogen chloride had subsided. Thereafter, the solvent was evaporated off under reduced pressure and the residue was recrystallized from ethyl acetate. 26 g of 2-chloroacetylamino-3-cyano-4,5-dimethylfurane of melting point 114° C. were obtained in this manner.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04240820 |
| 出典データセット | uspto-grants-1980_12 |
| ORD ID | ord-732f528106744e908873ac48e9d38c0e |
| 出典メモ | uspto-grants-1980_12 |