Acetic Acid → HCID 20300371、化合物

HRID 1733148ノート

反応式

HRID 1733148 の反応式
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[C:13](O)(=[O:15])[CH3:14].C(OC(=O)C)(=O)C>>[C:13]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8])(=[O:15])[CH3:14]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 13770581HCID 13770581、化合物

生成物 1

HCID 20300371HCID 20300371、化合物収率 83.4%

実験手順

16.4 g (0.1 mole) of 2-amino-3-cyano-4-tert.-butylfuran were heated to 100° C. with 24 ml (0.4 mole) of acetic acid and 10.4 ml (0.11 mole) of acetic anhydride for one hour. Thereafter, the reaction mixture was evaporated under reduced pressure and the residue was recrystallized from a mixture of toluene/cyclohexane (1:2). 17.2 g of 2-acetylamino-3-cyano-4-tert.-butyl-furan of melting point 135° C. were obtained in this manner.

後処理

  1. customThereafter, the reaction mixture was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixture of toluene/cyclohexane (1:2)

出典と根拠

ORDレコード
ord-906e8f6c272a4d838725e739580d17b5
出典データセット
uspto-grants-1980_12
特許番号
US04240820

反応ノート

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