Hydrochloric Acid → 3-Oxo-3-(thiophen-3-yl)propanenitrile

HRID 1733304ノート

反応式

HRID 1733304 の反応式
N[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)=[CH:3][C:4]#[N:5].Cl.C[OH:13]>>[O:13]=[C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH2:3][C:4]#[N:5]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54536012beta-Amino-3-thiopheneacrylonitrile

生成物 1

HCID 27400753-Oxo-3-(thiophen-3-yl)propanenitrile

実験手順

A 1.2 g. portion of β-amino-3-thiopheneacrylonitrile is added to 10 ml. of 1 N hydrochloric acid. A 40 ml. portion of methanol is added and the mixture is stirred for 3 hours. The mixture is evaporated in vacuo to a residue which is dissolved in 35 ml. of hot methanol and treated with charcoal. After cooling, petroleum ether is added, the mixture is filtered and the solid collected is discarded. The filtrate is allowed to evaporate and the residue is dissolved in 35 ml. of hot isopropanol and isoluble material filtered and discarded The filtrate is cooled and the solid is collected giving the desired product as white plates, m.p. 87°-88° C.

後処理

  1. customThe mixture is evaporated in vacuo to a residue which
  2. dissolutionis dissolved in 35 ml
  3. additionof hot methanol and treated with charcoal
  4. temperatureAfter cooling
  5. additionpetroleum ether is added
  6. filtrationthe mixture is filtered
  7. customthe solid collected
  8. customto evaporate
  9. dissolutionthe residue is dissolved in 35 ml
  10. filtrationof hot isopropanol and isoluble material filtered
  11. temperatureis cooled
  12. customthe solid is collected

出典と根拠

ORDレコード
ord-3bc6011f6acb4146adb1f9389d601cef
出典データセット
uspto-grants-1980_12
特許番号
US04241077

反応ノート

読み込み中…