HCID 178508524、化合物 → HCID 178460095、化合物

HRID 1733360ノート

反応式

HRID 1733360 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>C(OC(=O)CC)(=O)CC>[NH2:9][C:5]1[C:6]([OH:8])=[N:7][C:2]([NH:1][C:6](=[O:8])[CH2:5][CH3:4])=[N:3][CH:4]=1

参加物

3

反応物 1

HCID 178508524HCID 178508524、化合物

生成物 1

HCID 178460095HCID 178460095、化合物

試薬・触媒・溶媒 1

HCID 31263Propionic anhydride溶媒

実験手順

7.8 gm (0.055 mol) of 2-amino-4-hydroxy-5-nitropyrimidine are heated for 4 hours to 140° C. in 50 ml of propionic acid anhydride. The mixture is cooled and the precipitated product is extracted and washed with ether. The compound is suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature and normal pressure with 1 gm of Pd/C as catalyst.

後処理

  1. temperatureThe mixture is cooled
  2. extractionthe precipitated product is extracted
  3. washwashed with ether
  4. customis suspended in 200 ml of dimethyl formamide and hydrogenated at room temperature

出典と根拠

ORDレコード
ord-6780981f04054bb19670ac98233bcbaf
出典データセット
uspto-grants-1980_12
特許番号
US04241056

反応ノート

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