Hydrochloric Acid → 3-Chloro-8-(1-piperazinyl)imidazo[1,2-a]pyrazine

反応式

[Cl:1][C:2]1[N:6]2[CH:7]=[C:8](Cl)[N:9]=[C:10]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:5]2=[N:4][CH:3]=1.Cl>O>[Cl:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([N:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[C:5]2=[N:4][CH:3]=1

参加物

実験手順

Employing the procedure substantially as described in Example 2, Step B, but substituting for the starting material used therein an equimolecular amount of each of 3,6-dichloroimidazo[1,2-a]pyrazine and 8-bromo-3,6-dichloroimidazo[1,2-a]pyrazine, there is produced respectively: 3-chloro-6-(1-piperazinyl)imidazo[1,2-a]pyrazine. HCl.1/2 H2O (m.p. >300° C.); and 3,6-dichloro-8-(1-piperazinyl)imidazo[1,2-a]pyrazine.HCl (m.p. >350° C.).