Propargylamine → 6-Chloro-5-(2-propyn-1-ylamino)-2-pyrazinecarboxylic acid

HRID 1733467ノート

反応式

HRID 1733467 の反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][C:5]([C:9]([OH:11])=[O:10])=[CH:4][N:3]=1.[NH2:12][CH2:13][C:14]#[CH:15]>O1CCOCC1>[Cl:8][C:7]1[C:2]([NH:12][CH2:13][C:14]#[CH:15])=[N:3][CH:4]=[C:5]([C:9]([OH:11])=[O:10])[N:6]=1

参加物

4

反応物 2

HCID 239041PropargylamineHCID 202996445,6-Dichloropyrazine-2-carboxylic acid

生成物 1

HCID 202996246-Chloro-5-(2-propyn-1-ylamino)-2-pyrazinecarboxylic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 2,3-dichloropyrazine-5-carboxylic acid (19.3 g, 0.100 mole) and 3-amino-1-propyne (1.10 g, 0.20 mole) in 100 ml dioxane is refluxed for 24 hours, cooled and concentrated under vacuum. The residue is partitioned between aqueous sodium bicarbonate and chloroform and the aqueous extract neutralized with acetic acid to give a precipitate of 3-chloro-2-(2-propyn-1-ylamino)pyrazine-5-carboxylic acid.

後処理

  1. temperatureis refluxed for 24 hours
  2. temperaturecooled
  3. concentrationconcentrated under vacuum
  4. customThe residue is partitioned between aqueous sodium bicarbonate and chloroform
  5. extractionthe aqueous extract

出典と根拠

ORDレコード
ord-21e9929954bc4d0b8f2691a5f480b50c
出典データセット
uspto-grants-1980_12
特許番号
US04242344

反応ノート

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