O-methylhydroxylammonium chloride → 1-Benzyl-4-methoxyiminopiperidine

HRID 1733480

反応式

HRID 1733480 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:16][O:17][NH3+:18]>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[N:18][O:17][CH3:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 11639O-methylhydroxylammonium chlorideHCID 192201-Benzyl-4-piperidone

生成物 1

HCID 119596661-Benzyl-4-methoxyiminopiperidine

実験手順

The starting material is prepared as follows: The solution of 94.5 g of 1-benzyl-4-piperidone and 46 g of methoxyammonium chloride in 600 ml of ethanol-pyridine (1:1) is refluxed overnight and evaporated. The residue is dissolved in water, the solution made basic with 12.5% aqueous sodium hydroxide and extracted with diethyl ether. The extract is washed with water and saturated aqueous sodium hydroxide, dried and evaporated, to yield the 1-benzyl-4-methoxyiminopiperidine.

後処理

  1. customThe starting material is prepared
  2. customevaporated
  3. dissolutionThe residue is dissolved in water
  4. extractionextracted with diethyl ether
  5. washThe extract is washed with water and saturated aqueous sodium hydroxide
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-e731adbf9a984c4aac164a4561121550
出典データセット
uspto-grants-1980_12
特許番号
US04242347

関連ノート

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