5-(4-Chlorophenyl)-2-hydrazinopyridine → 6-(4-Chlorophenyl)-3-methyl-1,2,4-triazolo[4,3-a]pyridine
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][NH2:15])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.[C:16]([O-])([O-])(OCC)[CH3:17]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]3[N:12]([C:16]([CH3:17])=[N:15][N:14]=3)[CH:13]=2)=[CH:4][CH:3]=1参加物
3
実験手順
A mixture of 8.5 g. of 5-(4-chlorophenyl)-2-hydrazinopyridine and 80 ml. of ethyl orthoacetate is refluxed for 5 hours, the mixture is filtered and the solid is washed with hexane to afford 5.0 g. of the product of the Example as a tan solid, m.p. 192°-193.5° C.
後処理
- additionA mixture of 8.5 g
- filtrationthe mixture is filtered
- washthe solid is washed with hexane
- customto afford 5.0 g
出典と根拠
- ORDレコード
- ord-741fdbed7f9a4dbfa7c1801cfccdb982
- 出典データセット
- uspto-grants-1980_12
- 特許番号
- US04242515
反応ノート
読み込み中…