Malonamide → 1,2-Dihydro-2-oxo-5-[3-(trifluoromethyl)phenyl]-3-pyridinecarboxamide

反応式

[C:1]([NH2:7])(=[O:6])[CH2:2][C:3]([NH2:5])=[O:4].C[O-].[Na+].CN(C)[CH:13]=[C:14]([C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1)[CH:15]=O>CO>[O:4]=[C:3]1[C:2]([C:1]([NH2:7])=[O:6])=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:26])[F:25])[CH:18]=2)=[CH:13][NH:5]1

参加物

実験手順

To a solution of 1.1 g. of malonamide and 1.1 g. of sodium methoxide in 50 ml. of methanol is added 2.43 g. of 3-(dimethylamino)-2-[3-(trifluoromethyl)phenyl]-2-propenal. The resulting mixture is heated at reflux temperature for 12 hours. The mixture is cooled, concentrated and acidified with hydrochloric acid to yield 800 mg. of the product of the Example as a yellow solid m.p. 276.5°-278.5° C.