Sulfuryl chloride → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 1733598ノート

反応式

HRID 1733598 の反応式
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([OH:10])[CH:8]=[C:7]([CH3:11])[S:6]1)=[O:4].S(Cl)(Cl)(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH3:11])=[CH:8][C:9]=1[OH:10])=[O:4]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 537769093-Hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester

生成物 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylate収率 75%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

17.4 parts of 3-hydroxy-5-methyldihydrothiophene-2-carboxylic acid methyl ester are dissolved in 100 parts by volume of methylene chloride. 14.9 parts of sulfuryl chloride in 20 parts by volume of methylene chloride are added in the course of 30 minutes at 10° C., whilst passing nitrogen into the mixture. The mixture is then distilled. 12.9 parts (75% of theory) of 3-hydroxy-5-methylthiophene-2-carboxylic acid methyl ester of boiling point 67°-70° C./0.3 mbar are obtained.

後処理

  1. distillationThe mixture is then distilled

出典と根拠

ORDレコード
ord-7618a4e722824172ad79f4d0fac56473
出典データセット
uspto-grants-1980_12
特許番号
US04242518

反応ノート

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