化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → Ethyl N-(1-((benzyloxy)carbonyl)-L-prolyl)-L-leucinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
| 反応物 | L-Leucine, ethyl ester, hydrochloride (1:1) | HCID 11658447 | — |
| 反応物 | 4-Oxo-3,4-dihydro-3-methanesulfonyloxy-1,2,3-benzotriazine | HCID 21896281 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl N-(1-((benzyloxy)carbonyl)-L-prolyl)-L-leucinate | HCID 6453075 | 66.4% |
反応手順
N-Benzyloxycarbonyl-L-proline (1.25 g), L-leucine ethyl ester hydrochloride (1.00 g) and N-methylmorpholine (1.10 ml) are dissolved in chloroform (10 ml) and thereto is added 4-oxo-3,4-dihydro-3-methanesulfonyloxy-1,2,3-benzotriazine (1.20 g). After allowing to stand overnight, to the mixture are added water and ethyl acetate. The ethyl acetate layer is washed and dried, and then the solvent is distilled off to give N-(N-benzyloxycarbonyl-L-prolyl)-L-leucine ethyl ester (1.3 g), melting point: 65°-67° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04242507 |
| 出典データセット | uspto-grants-1980_12 |
| ORD ID | ord-89cf0924f3e74005978288a0de1fd424 |
| 出典メモ | uspto-grants-1980_12 |