N-Methylaniline → Ethyl 5-[methyl(phenyl)amino]pentanoate
反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)(O)[O-].[Na+]>>[CH3:1][N:2]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of N-methylaniline (16 g) and ethyl 5-bromovalerate (30.2 g) was stirred at 110° C. for 22 hours. Then the mixture was made alkaline with an aqueous sodium bicarbonate. The resulting mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated. The residue was distilled under reduced pressure to obtain ethyl 5-(N-methylanilino)valerate (28.6 g).
後処理
- extractionThe resulting mixture was extracted with ethyl acetate
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
- distillationThe residue was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-58856c818b6a455fb81177fa567be544
- 出典データセット
- uspto-grants-1996_07
- 特許番号
- US05532171
反応ノート
読み込み中…