Hydrochloric Acid → HCID 19438839、化合物

反応式

Cl.[C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][CH2:30][CH2:29][C:28]=3[CH:32]=2)[CH2:20][CH2:19]1)([OH:4])=[O:3].[CH3:33]O>>[CH3:33][O:3][C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]2[CH:25]=[CH:26][C:27]3[O:31][CH2:30][CH2:29][C:28]=3[CH:32]=2)[CH2:22][CH2:23]1)=[O:4]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 19438859HCID 19438859、化合物

生成物 1

HCID 19438839HCID 19438839、化合物

実験手順

HCl gas is passed into a boiling solution of 2.5 g of 1-[4-(5-carboxyindol-3-yl)butyl]-4-(2,3-dihydrobenzofuran-5-yl)piperazine in 50 ml of absolute methanol for 2 hours. The mixture is then boiled for a further hour, worked up in the customary manner and gives 1-[4-(5-methoxycarbonylindol-3-yl)butyl]-4-(2,3-dihydrobenzofuran-5-yl)piperazine.

後処理

waitThe mixture is then boiled for a further hour

出典と根拠

ORDレコード: ord-05f7ed1222354e04901a6e70063b4aa9
出典データセット: uspto-grants-1996_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05532241

反応ノート

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