Methylhydrazine → HCID 19438749、化合物
反応式
[Cl:1][C:2]1[S:11][C:10]2[C:9](=O)[C:8](=[CH:13][N:14](C)[CH3:15])[CH2:7][CH2:6][N:5]([C:17](=[O:27])[C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=3)[C:4]=2[CH:3]=1.C[NH:29]N>CO>[Cl:1][C:2]1[S:11][C:10]2[C:9]3=[N:29][N:14]([CH3:15])[CH:13]=[C:8]3[CH2:7][CH2:6][N:5]([C:17](=[O:27])[C:18]3[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[CH:22][CH:23]=3)[C:4]=2[CH:3]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 500 mg of 2-chloro-7-[(dimethylamino)methylene]-4,5,6,7-tetrahydro-4-(4-nitrobenzoyl)-8H-thieno[3,2-b]azepin-8-one in 15 ml of absolute methanol is stirred under argon while 131 μl of N-methylhydrazine is added. The reaction mixture is heated at 80° C. for 18 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to give 420 mg of the desired product as a solid.