1-[3-(Chloromethyl)-4-methoxyphenyl]ethan-1-one → HCID 3922617、化合物

HRID 1734020ノート

反応式

HRID 1734020 の反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]([C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C)C=O>[C:14]1(=[O:24])[N:18]([CH2:2][C:3]2[CH:4]=[C:5]([C:11](=[O:13])[CH3:12])[CH:6]=[CH:7][C:8]=2[O:9][CH3:10])[C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12

参加物

4

反応物 2

HCID 27767231-[3-(Chloromethyl)-4-methoxyphenyl]ethan-1-oneHCID 24194345Phthalimide potassium salt

生成物 1

HCID 3922617HCID 3922617、化合物収率 76.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of 3'-chloromethyl-4'-methoxyacetophenone (10.0 g) in N,N-dimethylformamide (30 ml) was added slowly to a suspension of potassium phthalimide (9.4 g) in N,N-dimethylformamide (70 ml) at room temperature and then the mixture was stirred for 9 hours at room temperature. After removed of the insoluble material, the solvent was removed under reduced pressure. The residue was suspended in water (100 ml). The mixture was extracted with ethyl acetate (300 ml). The extract was dried with magnesium sulfate. The solvent was removed under reduced pressure to afford 3'-phthalimidomethyl-4'-methoxyacetophenone (11.94 g).

後処理

  1. customAfter removed of the insoluble material
  2. customthe solvent was removed under reduced pressure
  3. extractionThe mixture was extracted with ethyl acetate (300 ml)
  4. dry with materialThe extract was dried with magnesium sulfate
  5. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-b53026b57b1a4e2990d3755a75831a4c
出典データセット
uspto-grants-1996_07
特許番号
US05532258

反応ノート

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