Hydrochloric Acid → 2-Methoxy-4-methylpyridin-3-amine

HRID 1734121ノート

反応式

HRID 1734121 の反応式
C(OC([NH:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15])=O)(C)(C)C.Cl>CCOC(C)=O>[NH2:8][C:9]1[C:10]([O:16][CH3:17])=[N:11][CH:12]=[CH:13][C:14]=1[CH3:15]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 10082908Tert-butyl 2-methoxy-4-methylpyridin-3-ylcarbamate

生成物 1

HCID 103293612-Methoxy-4-methylpyridin-3-amine収率 100%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-(tert-Butoxycarbonylamino)-2-methoxy-4-methylpyridine (0.7 g, 2.9 mmol) was treated with 25 mL of 4M HCl in EtOAc at room temperature overnight. The resulting suspension was carefully washed with sat. NaHCO3, dried (MgSO4) and concentrated to give 0.4 g of the free amine as an oil (100%). m.p. (HCl salt): 199° C. (d).

後処理

  1. washThe resulting suspension was carefully washed with sat. NaHCO3
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-9ff4367edf7e4ff59a9646f0405f517f
出典データセット
uspto-grants-1996_07
特許番号
US05532358

反応ノート

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