Hydrochloric Acid → rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

HRID 1734129ノート

反応式

HRID 1734129 の反応式
C([N:9]1[CH2:17][C@@H:16]2[C@@H:11]([N:12]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][CH2:14][O:15]2)[CH2:10]1)(=O)C1C=CC=CC=1.Cl>O>[CH2:18]([N:12]1[C@@H:11]2[C@@H:16]([CH2:17][NH:9][CH2:10]2)[O:15][CH2:14][CH2:13]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 53682667cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

生成物 1

HCID 10856960rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

91 g (0.265 mol) of cis-8-benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane with 200 ml of concentrated hydrochloric acid and 140 ml of water are heated under reflux overnight. After cooling, the benzoic acid is filtered off with suction, the solution is reduced to half the volume and made alkaline with potassium carbonate and extracted with chloroform, the extract is dried over potassium carbonate, concentrated and distilled.

後処理

  1. temperatureunder reflux overnight
  2. temperatureAfter cooling
  3. filtrationthe benzoic acid is filtered off with suction
  4. extractionextracted with chloroform
  5. dry with materialthe extract is dried over potassium carbonate
  6. concentrationconcentrated
  7. distillationdistilled

出典と根拠

ORDレコード
ord-3314c8c7bbbe4724b2dad6e1eea99ccd
出典データセット
uspto-grants-1996_07
特許番号
US05532364

反応ノート

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