Ammonia → RO-05-2921

HRID 1734324

反応式

HRID 1734324 の反応式
Br[CH2:2][C:3]([NH:5][C:6]1[CH:19]=[CH:18][CH:17]=[CH:16][C:7]=1[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=O)=[O:4].[NH3:20].O>CO>[C:10]1([C:8]2[C:7]3[CH:16]=[CH:17][CH:18]=[CH:19][C:6]=3[NH:5][C:3](=[O:4])[CH2:2][N:20]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 962WaterHCID 84439N-(2-Benzoylphenyl)-2-bromoacetamide

生成物 1

HCID 76175RO-05-2921収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A suspension of 2-bromoacetamidobenzophenone (275 g, 0.86 mol) in methanol (1 L) was treated with a solution of saturated ammonia in methanol (3 L), and the resulting solution was stirred at ambient temperature for 6 h, then was heated at reflux for an additional 4 h. After cooling, water (500 mL) was added, and the solution was concentrated by evaporation to about 1 L in volume, yielding crystalline 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (20) (200.7 g, 98%).

後処理

  1. temperaturewas heated
  2. temperatureat reflux for an additional 4 h
  3. temperatureAfter cooling
  4. concentrationthe solution was concentrated by evaporation to about 1 L in volume

出典と根拠

ORDレコード
ord-a0826e8108a34c36a4b1e6d5676bbd6a
出典データセット
uspto-grants-1996_07
特許番号
US05532359

関連ノート

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