N1-isopropyl-4-chloro-2-nitroaniline → HCID 19437878、化合物
反応式
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6][CH:7]([CH3:9])[CH3:8])=[C:4]([N+:12]([O-])=O)[CH:3]=1.[N+:15]([O-:18])(O)=[O:16].[C:19](OC(=O)C)(=[O:21])C>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[C:11]([N+:15]([O-:18])=[O:16])=[CH:10][C:5]2[N:6]([CH:7]([CH3:8])[CH3:9])[C:19](=[O:21])[NH:12][C:4]=2[CH:3]=1参加物
4
実験手順
The compound of Example 4 (1.0 g, 5.0 mmol) was suspended in acetic anhydride (10 mL) and cooled in an ice bath. To this mixture was added dropwise 1.5 mL of a 1:2 mixture of nitric acid/acetic anhydride. The reaction mixture was stirred for 5 minutes before being poured into ice-water. The solid was filtered and washed well with water and suction-dried to afford 1.01 g (80%) of the title compound as a solid.
後処理
- temperaturecooled in an ice bath
- additionTo this mixture was added dropwise
- filtrationThe solid was filtered
- washwashed well with water
- customsuction-dried
出典と根拠
- ORDレコード
- ord-5de67d1ef5bd48728f22d935007e5fa6
- 出典データセット
- uspto-grants-1996_07
- 特許番号
- US05534521
反応ノート
読み込み中…