1,3,8-Triazaspiro(4.5)decane-2,4-dione, 8-methyl- → 4-Amino-1-methylpiperidine-4-carboxylic acid
反応式
[CH3:1][N:2]1[CH2:13][CH2:12][C:5]2([NH:9]C(=O)N[C:6]2=[O:11])[CH2:4][CH2:3]1.[OH2:14].O.O.O.O.O.O.O.[OH-].[Ba+2].[OH-]>O>[NH2:9][C:5]1([C:6]([OH:11])=[O:14])[CH2:4][CH2:3][N:2]([CH3:1])[CH2:13][CH2:12]1参加物
4
実験手順
1-Methylpiperidine-4-spiro-5'-hydantoin (9.75 g, 0.0533 mole) and barium hydroxide octahydrate (28.8 g, 0.0913 mole) in water (150 ml) were heated at 160° C. in a bomb for 3 hr. The content of four such batches were combined and the precipitated barium carbonate was filtered off. The filtrate was neutralized with solid CO2 and the precipitate removed by filtration. The filtrate was concentrated to give 4-amino-1-methylpiperidine-4-carboxylic acid (32.0 g., 95%) mp. 275°-280° C. (dec.).
後処理
- filtrationthe precipitated barium carbonate was filtered off
- customthe precipitate removed by filtration
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-8ca3b7d6988948eaa0d60a00f9163b9b
- 出典データセット
- uspto-grants-1996_07
- 特許番号
- US05534520
反応ノート
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