N-trityl-2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine → 2-[4-(Benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride
反応式
C([NH:20][CH2:21][CH2:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[O:32][C:33]3[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=3[N:35]=2)=[CH:27][CH:26]=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:40].CCO>CCO>[ClH:40].[O:32]1[C:33]2[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=2[N:35]=[C:31]1[C:28]1[CH:29]=[CH:30][C:25]([CH2:24][O:23][CH2:22][CH2:21][NH2:20])=[CH:26][CH:27]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
N-trityl-2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine (9.1 g; 17.8 mmol) is suspended in EtOH and treated with HCl/EtOH until acidic by pH paper. The reaction mixture is heated at 80° C. for 3 hours keeping the reaction acidic. The reaction mixture is then cooled and the solid is filtered and washed with EtOH to give 2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride (m.p. 232°-233° C.) as a white solid which is used directly in Step F.