Triethylamine → Acetaldehyde, 2-(2-phenylethoxy)-
反応式
[C:1]1([CH2:7][CH2:8][O:9][CH2:10][CH2:11][OH:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC>CS(C)=O.C(Cl)Cl.CCOCC>[C:1]1([CH2:7][CH2:8][O:9][CH2:10][CH:11]=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
5
実験手順
To 2-(2-phenylethoxy)-1-ethanol (0.25 g; 1.5 mmol) [J. Med. Chem., 1570 (1983)] dissolved in DMSO/CH2Cl2 (4 ml/2 ml) is added Et3N (1 ml; 7 mmol) followed by sulfur trioxide pyridine complex (1.2 g; 7.5 mmol). After 10 minutes, the reaction mixture is then diluted with Et2O and washed with brine, 1N HCl, NaHCO3 and brine, dried (MgSO4) and concentrated in yacuo to dryness. The residue is purified by column chromatography using CH2Cl2 to obtain 2-phenylethoxyacetaldehyde which is used directly in Step B.
後処理
- washwashed with brine, 1N HCl, NaHCO3 and brine
- dry with materialdried (MgSO4)
- concentrationconcentrated in yacuo to dryness
- customThe residue is purified by column chromatography
出典と根拠
- ORDレコード
- ord-9e466377c4664e4c80ae701d3f432f95
- 出典データセット
- uspto-grants-1996_07
- 特許番号
- US05534532
反応ノート
読み込み中…