N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamide → N-[2-ethyl-6-(1-hydroxy-3-phenylpropyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

HRID 1734865ノート

反応式

HRID 1734865 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]=[O:10])[C:4]=1[NH:11][C:12](=[O:28])[CH2:13][CH:14]1[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:21][C:20]2[C:15]1=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:2].[CH2:29]([Mg]Br)[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH:9]([OH:10])[CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:4]=1[NH:11][C:12](=[O:28])[CH2:13][CH:14]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=2[O:21][C:22]2[C:27]1=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH3:2]

参加物

3

反応物 2

HCID 19966259N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamideHCID 178419670HCID 178419670、化合物

生成物 1

HCID 19966244N-[2-ethyl-6-(1-hydroxy-3-phenylpropyl)phenyl]-2-(9H-xanthen-9-yl)acetamide

実験手順

Following a procedure similar to that described in Example 14, but using N-(2-ethyl-6-formylphenyl)-2-(9H-xanthen-9-yl)acetamide (prepared by a procedure similar to that described in Preparation 29) and phenethylmagnesium bromide as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as crystals, melting at 128°-129° C. (after recrystallization from a mixture of ethyl acetate and hexane).

後処理

  1. customprepared by a procedure similar to

出典と根拠

ORDレコード
ord-3fa1b81e853a4514aa0f5c14d0d1c30e
出典データセット
uspto-grants-1996_07
特許番号
US05534529

反応ノート

読み込み中…