Water → Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

HRID 1735111ノート

反応式

HRID 1735111 の反応式
Cl[C:2]1[N:3]([CH3:16])[C:4]2[C:9]([C:10]=1[CH:11]=O)=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2.C([O-])([O-])=O.[K+].[K+].[SH:23][CH2:24][C:25]([O:27][CH3:28])=[O:26].O>CO>[CH3:16][N:3]1[C:4]2[C:9](=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[CH:6][CH:5]=2)[C:10]2[CH:11]=[C:24]([C:25]([O:27][CH3:28])=[O:26])[S:23][C:2]1=2

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 108238742-Chloro-1-methyl-5-nitroindole-3-carbaldehyde

生成物 1

HCID 19068989Methyl 8-methyl-5-nitrothieno[2,3-b]indole-2-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.4 g of (66) was added to a slurry of excess K2CO3 in 100 ml of MeOH. 2 ml of methyl 2-mercaptoacetate was added and the mixture left with stirring overnight. Addition of water precipitated the product, which was washed with MeOH and water to give 640 mg of (67). M.p. 269°-71° C.

後処理

  1. waitthe mixture left
  2. customprecipitated the product, which
  3. washwas washed with MeOH and water

出典と根拠

ORDレコード
ord-dc9b21c0ec074569b51db4d9f7fb9792
出典データセット
uspto-grants-1996_07
特許番号
US05536721

反応ノート

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