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Pamoic Acid → Octreotide pamoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pamoic Acid | HCID 8546 | — |
| 反応物 | Octreotide | HCID 448601 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | Octreotide pamoate | HCID 44194024 | — |
反応手順
10.19 g of octreotide free base (10 mM) and 3.88 embonic acid (10 mM) are dissolved in 1 liter of water/dioxane (1:1). The reaction mixture is filtered, and lyophilized to give a yellow powder [α]20D=+7.5° (C=0.35, in DMF), of octreotide pamoate hydrate. Factor=1.4 wherein the factor=weight of lyophilizate/weight of octreotide contained therein.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05538739 |
| 出典データセット | uspto-grants-1996_07 |
| ORD ID | ord-b47e8b278e13464894097467ad20f6c6 |
| 出典メモ | uspto-grants-1996_07 |