1-Bromo-4-fluorobenzene → Stannane, (4-fluorophenyl)trimethyl-

HRID 1736298ノート

反応式

HRID 1736298 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[CH:4][CH:3]=1.C([Li])CCC.[CH3:14][Sn:15](Cl)([CH3:17])[CH3:16]>C(OCC)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([Sn:15]([CH3:17])([CH3:16])[CH3:14])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 99931-Bromo-4-fluorobenzeneHCID 14016Trimethyltin chlorideHCID 178418339Butyllithium

生成物 1

HCID 618619Stannane, (4-fluorophenyl)trimethyl-収率 28.8%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

3.0 g (13 mmol) of 4-fluorobromobenzene, 100 ml of anhydrous diethyl ether, 12 ml (19 mmol) of 1.6 M n-butyllithium (hexane solution) and 3.8 g (19 mmol) of trimethyltin chloride were subjected to reaction, treatment and purification in the same manner as in Example 13 (a) to give 970 mg of 4-flurophenyltrimethyltin as a colorless oil (yield 22%).

出典と根拠

ORDレコード
ord-09b803c6dd774a7d87401f36e6ea935c
出典データセット
uspto-grants-1996_07
特許番号
US05541169

反応ノート

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