Morpholine → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

HRID 1736597ノート

反応式

HRID 1736597 の反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

参加物

3

反応物 2

HCID 8083MorpholineHCID 5686382-Chloro-4-cyanopyridine

生成物 1

HCID 146408562-(Morpholin-4-yl)pyridine-4-carbonitrile収率 53%

実験手順

A mixture of 2-chloro-4-cyanopyridine (2.5 g, 18 mmol) and morpholine (6.29 g, 72 mmol) was heated at 110°-120° C. for 4 hours. The reaction mixture was cooled, poured into ice-water (15 ml) and stirred for 30 minutes. A yellow solid was obtained, which was collected by filtration, washed with water and dried in vacuo at 70° C. in the presence of P2O5 to afford 1.8 g (53%) of 2-(4-morpholinyl)-4-cyanopyridine, m.p. 135°-136.5° C.

後処理

  1. temperaturewas heated at 110°-120° C. for 4 hours
  2. temperatureThe reaction mixture was cooled
  3. customA yellow solid was obtained
  4. filtrationwhich was collected by filtration
  5. washwashed with water
  6. dry with materialdried in vacuo at 70° C. in the presence of P2O5

出典と根拠

ORDレコード
ord-5f0feb342a70407baf953be5a6d37ce9
出典データセット
uspto-grants-1996_07
特許番号
US05541187

反応ノート

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