2-Benzylidenecyclohexanone → HCID 12118799、化合物

HRID 1737175ノート

反応式

HRID 1737175 の反応式
[CH:1](=[C:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].CO>[CH2:1]([C@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:1]([C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 1

HCID 989262-Benzylidenecyclohexanone

生成物 2

HCID 12118799HCID 12118799、化合物収率 88%HCID 12283992Cyclohexanol, 2-(phenylmethyl)-, cis-

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Then, 10 g of 2-benzylidenecyclohexanone were hydrogenated at room temperature using 1 g of Raney nickel in methanol under hydrogen pressure (3 kg/cm2) until the absorption of hydrogen was stopped. After an organic layer was collected by decantation and concentrated, the residue was purified by column chromatography, thereby obtaining 4.6 g of cis-2-benzylcyclohexanol and 4.4 g of trans-2-benzylcyclohexanol (yield: 88% in total).

後処理

  1. customwere hydrogenated at room temperature
  2. customuntil the absorption of hydrogen
  3. customAfter an organic layer was collected by decantation
  4. concentrationconcentrated
  5. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-66b69874a6dd4b8db91e126567b090d3
出典データセット
uspto-grants-1999_10
特許番号
US05962403

反応ノート

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