Hydrochloric Acid → (S)-8-chloro-1-(4-diallylaminomethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride

HRID 1737369ノート

反応式

HRID 1737369 の反応式
[Cl:1][C:2]1[C:7]2[C:8](=[O:32])[N:9]3[CH2:31][CH2:30][CH2:29][C@H:10]3[C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[S:17][CH:18]=[C:19]([CH2:21][N:22]([CH2:26][CH:27]=[CH2:28])[CH2:23][CH:24]=[CH2:25])[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl>O>[ClH:1].[Cl:1][C:2]1[C:7]2[C:8](=[O:32])[N:9]3[CH2:31][CH2:30][CH2:29][C@H:10]3[C:11]3[N:12]([CH:13]=[N:14][C:15]=3[C:16]3[S:17][CH:18]=[C:19]([CH2:21][N:22]([CH2:23][CH:24]=[CH2:25])[CH2:26][CH:27]=[CH2:28])[N:20]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86753962(S)-8-chloro-1-(4-diallylaminomethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one

生成物 1

HCID 86753963(S)-8-chloro-1-(4-diallylaminomethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride収率 180.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

0.50 g (0.0011 mol) of (S)-8-chloro-1-(4-diallylaminomethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one was suspended in 10 ml of water and treated with 10.6 ml of 0.1N (0.00106 mol) aqueous hydrochloric acid. After stirring at room temperature for 1 hr. the mixture was filtered and the filtrate was lyophilized. There was obtained 0.50 g (95%) of (S)-8-chloro-1-(4-diallylaminomethyl-thiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride (1:1).

後処理

  1. filtrationthe mixture was filtered

出典と根拠

ORDレコード
ord-daa4af8c1f954acf826e00feb6886458
出典データセット
uspto-grants-1999_10
特許番号
US05962450

反応ノート

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