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3-(4-Fluorophenyl)-2-propenoic acid → 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| 反応物 | 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile | HCID 7537616 | — |
| 反応物 | Benzenepropanoic acid, 4-fluoro-, ethyl ester | HCID 11816416 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 生成物 | 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole | HCID 21843580 | — |
反応手順
1-[1-(4-cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole is prepared according to the procedure described in Example 1 starting from 1-(4-cyanobenzyl)-1,2,4-triazole (1.7 g, 0.0092 mol), n-BuLi (0.0108 mol) and ethyl 3-(4-fluorophenyl)propionate (2.3 g, 0.0117 mol) prepared from 4-fluorocinnamic acid by esterification and hydrogenation. The product is purified by flash chromatography methylene chloride-methanol (95:5) as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05962495 |
| 出典データセット | uspto-grants-1999_10 |
| ORD ID | ord-5bdc9d226d0f4139b19173e36e35b09e |
| 出典メモ | uspto-grants-1999_10 |