Hydrochloric Acid → HCID 178418437、化合物

HRID 1737935

反応式

HRID 1737935 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][C@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH3:27])[CH3:26])=[CH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:10])=[CH:4][CH:3]=1.Cl>C(OCC)C.C(O)(C)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][C@H:12]2[CH2:13][CH2:14][C@H:15]([C:18]3[CH:19]=[CH:20][C:21]([CH2:24][N:25]([CH3:26])[CH3:27])=[CH:22][CH:23]=3)[CH2:16][CH2:17]2)=[O:10])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 178418347HCID 178418347、化合物

生成物 1

HCID 178418437HCID 178418437、化合物

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 3776Isopropanol溶媒

実験手順

A solution of 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol in 10 ml of diethyl ether is combined at ambient temperature, with stirring, with a 1.5 times equimolar amount of hydrogen chloride in isopropanol added dropwise. The precipitate formed is left for 1 hour at ambient temperature, suction filtered, washed repeatedly with diethyl ether and dried. White crystals are obtained, melting point 231-233° C. Yield: 0.32 g (76% of theory). C23H29Cl2NO2 (422.40) Calculated: C 65.40 H 6.92 N 3.32 Cl 16.79 Found: 65.33 7.06 3.45 16.92

後処理

  1. customis combined at ambient temperature
  2. additionadded dropwise
  3. customThe precipitate formed
  4. filtrationsuction filtered
  5. washwashed repeatedly with diethyl ether
  6. customdried
  7. customWhite crystals are obtained

出典と根拠

ORDレコード
ord-73b2da3a71ba4351a5701078dc2ad8c9
出典データセット
uspto-grants-1999_10
特許番号
US05962507

関連ノート

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