Acetyl chloride → N-(3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl)acetamide

反応式

[CH2:1]([O-:3])[CH3:2].Cl.Cl.[NH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1.C(Cl)(=O)C>>[C:1]([NH:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)(=[O:3])[CH3:2]

参加物

反応物 2

HCID 6367Acetyl chloride

HCID 86751892HCID 86751892、化合物

生成物 1

HCID 22611622N-(3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl)acetamide収率 78.3%

実験手順

Beginning with 2.00 gm (5.74 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole dihydrochloride ethanolate and 1.13 gm (25.8 mMol) acetyl chloride, 1.22 gm (78.3%) of the title compound were recovered as a white powder.

出典と根拠

ORDレコード: ord-8cc981dda0e749c0b9c08dab1b86c4e1
出典データセット: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05962473

反応ノート

読み込み中…