Cyclohexanecarboxylic acid → 5-(cyclohexanecarbonyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole

反応式

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH:18]1([C:24](O)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:18]1([C:24]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

反応物 2

HCID 7413Cyclohexanecarboxylic acid

HCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

生成物 1

HCID 226115225-(cyclohexanecarbonyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole

実験手順

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 13.0 mg (0.10 mMol) cyclohexanecarboxylic acid, 20.6 mg (100+%) of the title compound were recovered.

出典と根拠

ORDレコード: ord-7b0b63ab249f41d2bfc48bd92d0620f3
出典データセット: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05962473

反応ノート

読み込み中…