Glycolic Acid → HCID 10849735、化合物

HRID 1738268ノート

反応式

HRID 1738268 の反応式
[NH2:1][C:2]1[C:3]([NH:15][CH3:16])=[N:4][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1.[C:17]([OH:21])(=O)[CH2:18]O>>[OH:21][CH2:17][C:18]1[N:15]([CH3:16])[C:3]2[C:2]([N:1]=1)=[CH:7][CH:6]=[C:5]([S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[N:4]=2

参加物

3

反応物 2

HCID 757Glycolic AcidHCID 105137093-Amino-2-methylamino-6-phenylthiopyridine

生成物 1

HCID 10849735HCID 10849735、化合物

実験手順

A procedure similar to that described in Preparation 43 was repeated, except that 2.62. g of 3-amino-2-methylamino-6-phenylthiopyridine (prepared as described in Preparation 89) and 2.58 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a gradient elution method, with mixtures of ethyl acetate and methanol in ratios ranging from 50:1 to 10:1 by volume as the eluent, to give 1.80 g of the title compound, melting at 119-120° C.

後処理

  1. customA procedure similar to that described in Preparation 43
  2. customthat the product was purified by column chromatography through silica gel
  3. washa gradient elution method

出典と根拠

ORDレコード
ord-31ae0f02e79a48d98e957ff6b809d9da
出典データセット
uspto-grants-1999_10
特許番号
US05962470

反応ノート

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