Phenylacetic Acid → 4-(2-Mesyloxyethoxy)phenyl benzylketone

HRID 1738618

反応式

HRID 1738618 の反応式
[CH3:1][S:2]([O:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[C:15]1([CH2:21]C(O)=O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:25]1([CH:31]([CH2:35][CH3:36])[C:32](O)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[S:2]([O:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:21]([C:32]([CH:31]([C:25]2[CH:30]=[CH:29][C:28]([O:8][CH2:7][CH2:6][O:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:27][CH:26]=2)[C:35]2[CH:36]=[CH:11][CH:10]=[CH:9][CH:14]=2)=[O:33])[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:11][CH:10]=1)([CH3:1])(=[O:4])=[O:3]

参加物

4

反応物 3

HCID 999Phenylacetic AcidHCID 70122-Phenylbutyric AcidHCID 2264992-Phenoxyethyl methanesulfonate

生成物 1

HCID 867545724-(2-Mesyloxyethoxy)phenyl benzylketone収率 80%

反応条件

温度
25 °C

実験手順

The oil comprising 2-Phenoxyethyl methanesulfonate was prepared as described above in Example 1. The acylation and workup procedure was identical to that of Example 1 with the exception that 30.26 g (220 mmol) 2-phenylacetic acid was reacted instead of the 2-phenylbutyric acid. The organic layer obtained by the workup procedure was cooled to 25° C. and stirred at this temperature for 1 hour. The resulting crystallized product was filtered, washed with toluene and dried under vacuum at 40° C. to yield 53.18 g (159 mmol) of the 4-(2-mesyloxyethoxy)phenyl benzylketone as a tan colored solid. Yield: 80% on 2-phenoxyethanol.

後処理

  1. customwas prepared
  2. customThe organic layer obtained by the workup procedure
  3. customThe resulting crystallized product
  4. filtrationwas filtered
  5. washwashed with toluene
  6. customdried under vacuum at 40° C.

出典と根拠

ORDレコード
ord-f59c121cca844a8bb94b070a82da3b2e
出典データセット
uspto-grants-1999_10
特許番号
US05962743

関連ノート

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