2-Fluoro-2-trifluoromethyl-4-octenamide → 2-Fluoro-2-trifluoromethyloctanamide

HRID 1738737ノート

反応式

HRID 1738737 の反応式
[F:1][C:2]([C:12]([F:15])([F:14])[F:13])([CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH3:11])[C:3]([NH2:5])=[O:4].[H][H]>CO.[C].[Pd]>[F:1][C:2]([C:12]([F:13])([F:15])[F:14])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[C:3]([NH2:5])=[O:4]

参加物

5

反応物 2

HCID 538353032-Fluoro-2-trifluoromethyl-4-octenamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 218389932-Fluoro-2-trifluoromethyloctanamide収率 76.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

Into a solution of 1.30 g of 2-fluoro-2-trifluoromethyl-4-octenamide in 13 ml of methanol, palladium-carbon (13 mg) was added under nitrogen. After the atmosphere was replaced with hydrogen, the mixture was stirred for 24 hours. To remove the catalyst, the resulting mixture was filtered with celite and the filtrate was concentrated. The raw product was purified by silica gel column chromatography to obtain 1.0 g of the desired compound.

後処理

  1. customTo remove the catalyst
  2. filtrationthe resulting mixture was filtered with celite
  3. concentrationthe filtrate was concentrated
  4. customThe raw product was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-ef76b54f5af44c2c907b8960f8b5f388
出典データセット
uspto-grants-1999_10
特許番号
US05965059

反応ノート

読み込み中…