2-Fluoro-2-trifluoromethyl-4-decenamide → 2-Fluoro-2-trifluoromethyldecanamide

HRID 1738739ノート

反応式

HRID 1738739 の反応式
[F:1][C:2]([C:14]([F:17])([F:16])[F:15])([CH2:6][CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:3]([NH2:5])=[O:4].[H][H]>CO.[C].[Pd]>[F:1][C:2]([C:14]([F:15])([F:17])[F:16])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:3]([NH2:5])=[O:4]

参加物

5

反応物 2

HCID 540171342-Fluoro-2-trifluoromethyl-4-decenamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 218389812-Fluoro-2-trifluoromethyldecanamide収率 120.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

Into a solution of 3.0 g (9.65 mmol) of 2-fluoro-2-trifluoromethyl-4-decenamide in 30 ml of methanol, palladium-carbon (75 mg) was added under nitrogen. After the atmosphere was replaced with hydrogen, the mixture was stirred for 24 hours. To remove the catalyst, the resulting mixture was filtered with celite and the filtrate was concentrated. The raw product was purified using silica gel column chromatography to obtain 3.0 g of the desired compound. The yield was 99.3%.

後処理

  1. customTo remove the catalyst
  2. filtrationthe resulting mixture was filtered with celite
  3. concentrationthe filtrate was concentrated
  4. customThe raw product was purified

出典と根拠

ORDレコード
ord-ee229ad94a7a4d8a899d0ed9eefad31b
出典データセット
uspto-grants-1999_10
特許番号
US05965059

反応ノート

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