Benzaldehyde → HCID 131720940、化合物

HRID 1738768ノート

反応式

HRID 1738768 の反応式
[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:13]([NH:15][NH2:16])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH:24](=O)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[H][H]>CO.[C].[Pd]>[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:13]([NH:15][NH:16][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

参加物

6

反応物 3

HCID 240BenzaldehydeHCID 7109657HCID 7109657、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 131720940HCID 131720940、化合物

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

In 600 ml of MeOH were dissolved 60.00 g of Boc-Trp-NHNH2 and 21.00 g of benzaldehyde, and the mixture was stirred in the presence of 3.80 g of 10% palladium carbon for 18 hours in a hydrogen stream. Subsequent procedures were carried out in the same manner as in Reference example 21 to obtain the title compound.

出典と根拠

ORDレコード
ord-e4b2da1b0c2b47f2a576a794e349cab4
出典データセット
uspto-grants-1999_10
特許番号
US05965538

反応ノート

読み込み中…