3-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazole → 3-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochloride

反応式

C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>>[ClH:21].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

参加物

反応物 2

HCID 154539363-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazole

HCID 204431481,4-Dioxane hydrochloride

生成物 1

HCID 186960233-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochloride収率 190.8%

実験手順

To 3-(2-(N-t-butoxycarbonylamino)-ethoxy)-5-chloro-1,2-benzisoxazole (0.50 g) was added a solution of 4N-hydrochloric acid/1,4-dioxane (4.0 ml) and stirred at room temperature for 15 minutes. After filtering the precipitated crystals and washing with 1,4-dioxane, the title compound (0.38 g) was obtained as colorless crystals.

後処理

filtrationAfter filtering the precipitated crystals
washwashing with 1,4-dioxane

出典と根拠

ORDレコード: ord-02e976f9efb04fb2a9364ef9adf78162
出典データセット: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05965591

反応ノート

読み込み中…

参加物