Aniline, 2,4-difluoro-6-nitro- → 1,3-Difluoro-5-nitrobenzene

HRID 1739540ノート

反応式

HRID 1739540 の反応式
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([N+:10]([O-:12])=[O:11])[C:3]=1N.N([O-])=O.[Na+]>>[F:1][C:2]1[CH:3]=[C:5]([N+:10]([O-:12])=[O:11])[CH:6]=[C:7]([F:9])[CH:8]=1

参加物

3

反応物 2

HCID 9697Aniline, 2,4-difluoro-6-nitro-HCID 23668193Sodium Nitrite

生成物 1

HCID 752721,3-Difluoro-5-nitrobenzene

実験手順

Thus WO 96/02493, starting from 2,4-difluoroaniline, discloses a synthesis proceeding via five stages. 2,4-Difluoroaniline is first reacted with acetic anhydride, the resulting acetanilide is nitrated by means of HNO3 /H2SO4, the acetyl radical is removed and 2,4-difluoro-6-nitroaniline is obtained. By reaction of the 2,4-difluoro-6-nitroaniline with sodium nitrite, the amino group can be removed and 3,5-difluoronitrobenzene is obtained, which can be converted into 3,5-difluoroaniline by reduction.

後処理

  1. customthe amino group can be removed

出典と根拠

ORDレコード
ord-3ff3a9bbdc754a158ade08b083195ec1
出典データセット
uspto-grants-1999_10
特許番号
US05965775

反応ノート

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