Water → 4-Benzylpiperazine-1-sulfonamide

HRID 1739737ノート

反応式

HRID 1739737 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:14](N)([NH2:17])(=[O:16])=[O:15].O>O1CCOCC1>[NH2:17][S:14]([N:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1)(=[O:16])=[O:15]

参加物

5

反応物 3

HCID 962WaterHCID 759941-BenzylpiperazineHCID 82267Sulfamide

生成物 1

HCID 112305864-Benzylpiperazine-1-sulfonamide収率 65.5%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 1-benzylpiperazine (5 g, 28.4 mmol) and sulphamide (2.77 g) in 1,4-dioxane (25 ml) was heated under reflux for 24 hours. The solution was cooled and poured into water (100 ml). The solid was filtered off, washed with toluene (100 ml) and dried under reduced pressure to give the title compound (4.75 g).

後処理

  1. temperatureunder reflux for 24 hours
  2. temperatureThe solution was cooled
  3. filtrationThe solid was filtered off
  4. washwashed with toluene (100 ml)
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ff5b110686c0465cad76b5e4ccf8d56d
出典データセット
uspto-grants-1999_10
特許番号
US05968923

反応ノート

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